Collaborative Stage for TNM 7 - Revised 11/15/2009 [ Schema ]
CS Site-Specific Factor 9
Vertical Growth Phase
- Note 1: The vertical growth phase (VGP) represents a stage of progression in which invasive melanoma cells have attained the capacity for survival and proliferation in the dermis which may then lead to the formation of an expansile tumor mass. Individual melanoma cells or small clusters of cells invading the superficial dermis do not necessarily represent vertical growth phase. While the presence of VGP is usually obvious in a thick melanoma, in a thin melanoma the minimal definition of VGP is the presence of 1 or more dermal clusters larger than the largest epidermal cluster (tumorigenic VGP) and/or the presence of any mitotic activity in the dermis (mitogenic VGP), either of which indicates the capacity for proliferation in the dermis. The VGP may occur in the presence or absence of an adjacent radial growth phase (RGP), which may be in situ or invasive. RGP is defined as melanoma without VGP. Nodular melanoma exhibits only a vertical growth phase without a radial growth phase; there may be an intraepidermal component above but not (beyond an arbitrary limit of 3 rete ridges) adjacent to the VGP.
- Note 2: Record the VGP as recorded in the pathology report. When the VGP is "not identified" registrars should code as absent.
|000||No vertical growth phase present|
Vertical growth phase not identified
Vertical growth phase absent
|001||Vertical growth phase present|
Information not collected for this case
|998||No histologic exam of primary site|
Not documented in patient record