Collaborative Stage

Note 1: There is evidence that HPV plays a role in the pathogenesis of some cancers. HPV testing may be performed for prognostic purposes; testing may also be performed on metastatic sites to aid in determination of the primary site.
Note 2: Record the results of any HPV testing performed on pathologic specimens from the primary tumor or a metastatic site, including lymph nodes. Do not record the results of blood tests or serology.
Note 3: HPVs are divided into high-risk and low-risk types. The highest risk HPV types are types 16 and 18. Other high-risk types are 26, 31, 33, 35, 36, 45, 51, 52, 53, 56, 58, 59, 66, 67, 68, 69, 70, 73, 82, and 85. The HPV vaccine is designed to protect against types 16 and 18 (associated with cervical cancer) and types 6 and 11 (associated with genital warts). Low-risk types are 6, 11, 32, 34, 40, 42, 44, 54, 61, 62, 64, 71, 72, 74, 81, 83, 84, 87, and 89.
Note 4: High-risk may be abbreviated hrHPV or HR-HPV.
Note 5: Some tests for HPV, such as a hybrid capture test, may only report negative or positive results for high-risk HPV without identifying types. Use codes 000 or 060, respectively, to report those test results.
Note 6: Codes 010-050 are hierarchical; use the highest code that applies.

Code	Description
000	HPV negative for high-risk and low-risk types HPV negative for high-risk types with no mention of low-risk types Negative, NOS
010	HPV positive for low-risk types only
020	HPV positive for specified high risk type(s) other than types 16 or 18
030	HPV positive for high-risk type 16 WITHOUT positive results for high-risk type18 or positivity of high-risk type 18 unknown
040	HPV positive for high-risk type18 WITHOUT positive results for high-risk type 16 or positivity of high-risk type 16 unknown
050	HPV positive for high-risk types16 AND 18
060	HPV positive for high-risk type(s), NOS, high-risk type(s) not stated
070	HPV positive, NOS, risk and type(s) not stated
888	OBSOLETE DATA CONVERTED V0200 See code 988 Not applicable for this site
988	Not applicable: Information not collected for this case (May include cases converted from code 888 used in CSv1 for "Not applicable" or when the item was not collected. If this item is required to drive T, N, M, or any stage, use of code 988 may result in an error.)
997	Test ordered, results not in chart
998	Test not done (test not ordered and not performed) No pathologic specimen available for HPV testing
999	Unknown or no information Not documented in patient record

CS Site-Specific Factor 1
Human Papilloma Virus (HPV) Status