Collaborative Stage

Note 1: O6-methylguanine-methyltransferase (MGMT) is an enzyme in cells that repairs DNA. DNA repair is undesirable in tumors, because they may be able to overcome the DNA damage done by chemotherapy. With methylation, less MGMT enzyme is produced, which may lead to prolonged survival compared to unmethylated MGMT.
Note 2: Code the methylation status of the MGMT gene (also termed MGMT promoter) as stated in the medical record. A positive test result may be termed "methylated," "hypermethylated," or "high." A negative result may be termed "unmethylated" or "low." This molecular test is not part of a routine pathology report.

Code	Description
010	Gene status methylated Hypermethylated High levels of methylation
020	Gene status unmethylated Low levels of methylation
888	OBSOLETE DATA CONVERTED V0200 See code 988 Not applicable for this site
988	Not applicable: Information not collected for this case (May include cases converted from code 888 used in CSv1 for "Not applicable" or when the item was not collected. If this item is required to derive T, N, M, or any stage, use of code 988 may result in an error.)
998	No histologic examination of primary site Test not done (test not ordered and not performed)
999	Unknown or no information Not documented in patient record

CS Site-Specific Factor 4
Methylation of O6-Methylguanine-Methyltransferase (MGMT)