Collaborative Stage

Note 1:
    A. In cases where ER is reported on more than one tumor specimen (except as noted in B and D), record the highest value.   If any sample is positive, record as positive.
    B. If neoadjuvant therapy is given, record the assay from tumor specimens prior to neoadjuvant therapy.
    C. If neoadjuvant therapy is given and there are no ER results from pre-treatment specimens, report the findings from post-treatment specimens.
    D: If the patient is ER positive and node negative, a multigene test such as OncotypeDX may be performed, in which case another ER test will be performed. Do not record the results of that test in this field. Record only the results of the test which made the patient eligible to be given the multigene test.
Note 2: In general, estrogen receptor (ER) assay is only performed on one sample. In cases where the assay is performed on more than one sample, there is not necessarily any reason to think that the most accurate is the test done on the "largest" tumor specimen. Clinically, treatment will be based on any positive test; with the benefit and minimal toxicity of hormonal therapy, most patients will be given the "benefit of the doubt" and treated with hormonal therapy if any ER test is positive.
Note 3: The most recent interpretation guidelines for ER do not allow for a borderline result. Therefore, code 030 will rarely be used. If 1% or greater cells stain positive, the test results are considered positive. If less than 1% of cells stain positive, the results are considered negative.

Code	Description
000	OBSOLETE DATA CONVERTED V0203 See code 998 Test not done (test not ordered and not performed)
010	Positive/elevated
020	Negative/normal; within normal limits
030	Borderline; undetermined whether positive or negative
080	OBSOLETE DATA CONVERTED V0203 See code 997 Ordered, but results not in chart
988	Not applicable: Information not collected for this case (If this item is required by your standard setter, use of code 988 will result in an edit error.)
996	Test ordered, results not interpretable
997	Test ordered, results not in chart
998	Test not done (test not ordered and not performed)
999	Unknown or no information Not documented in patient record

Breast

CS Site-Specific Factor 1
Estrogen Receptor (ER) Assay

Breast

CS Site-Specific Factor 1Estrogen Receptor (ER) Assay

CS Site-Specific Factor 1
Estrogen Receptor (ER) Assay