Collaborative Stage

Note 1: There is a clinical interest in triple negative breast cancer, or breast cancer that is negative for estrogen receptors (ER), progesterone receptors (PR), and Human Epidermal Growth Factor Receptor 2 (HER2) amplification or overexpression.
Note 2: This field is based on CS Site-Specific Factors 1, 2, and 15.
Note 3: ER results are coded in the first digit: 0 for negative and 1 for positive.
Note 4: PR results are coded in the second digit: 0 for negative and 1 for positive.
Note 5: HER2 results are coded in the third digit: 0 for negative and 1 for positive.
Note 6: If information is unknown or not available for one or more of the three types of tests, or if one or more of the three types of tests was not performed, code 999.

Code	Description
000	ER Negative, PR Negative, HER2 Negative (Triple Negative)
001	ER Negative, PR Negative, HER2 Positive
010	ER Negative, PR Positive, HER2 Negative
011	ER Negative, PR Positive, HER2 Positive
100	ER Positive, PR Negative, HER2 Negative
101	ER Positive, PR Negative, HER2 Positive
110	ER Positive, PR Positive, HER2 Negative
111	ER Positive, PR Positive, HER2 Positive
988	Not applicable: Information not collected for this case (If this information is required by your standard setter, use of code 988 may result in an edit error.)
999	One or more tests not performed One or more tests unknown if performed One or more tests with unknown or borderline results Unknown or no information Not documented in patient record

CS Site-Specific Factor 16
Combinations of ER, PR, and HER2 Results