Collaborative Stage

Note 1: Disseminated tumor cells (DTCs) are isolated tumor cells (ITCs) (micrometastases less than or equal to 0.2 mm) found in the bone marrow or other nonregional nodal tissues or organs.
Note 2: Immunohistochemistry (IHC) with cytokeratin stains and Reverse Transcription Polymerase Chain Reaction (RT-PCR) are laboratory methods for identifying very small amounts of tumor cells in tissue. RT-PCR amplifies genetic material identified by probes for tumor genes to a detectable level.
Note 3: Any positive test takes precedence over a negative or borderline test. Information about a known test takes precedence over no information about other tests.

Code	Description
010	Positive, Reverse Transcriptase Polymerase Chain Reaction (RT-PCR) test
020	Positive, immunohistochemistry (IHC) test
025	Positive on RT-PCR and IHC
030	Positive, other test type
040	Positive, unknown test type
110	Negative/normal, RT-PCR test
120	Negative/normal IHC test
130	Negative/normal, other test type
140	Negative/normal, unknown test type
210	Borderline; equivocal; indeterminate; undetermined if positive or negative, RT-PCR test
220	Borderline; equivocal; indeterminate; undetermined if positive or negative, IHC test
230	Borderline; equivocal; indeterminate; undetermined if positive or negative, other test type
240	Borderline; equivocal; indeterminate; undetermined if positive or negative, unknown test type
988	Not applicable: Information not collected for this case (If this information is required by your standard setter, use of code 988 may result in an edit error.)
997	Test ordered, results not in chart
998	Test not done (test not ordered and not performed)
999	Unknown or no information Not documented in patient record

CS Site-Specific Factor 18
Disseminated Tumor Cells (DTC) and Method of Detection