Collaborative Stage

Note 1: Definition of Adjacent Connective Tissue: Some of the schemes for ill-defined or non-specific sites in this manual contain a code 400, adjacent connective tissue, which is defined here as the unnamed tissues that immediately surround an organ or structure containing a primary cancer. Use this code when a tumor has invaded past the outer border (capsule, serosa, or other edge) of the primary organ into the organ's surrounding supportive structures but has not invaded into larger structures or adjacent organs.
Note 2: Definition of Adjacent Structures: Connective tissues large enough to be given a specific name would be considered adjacent structures. For example, the brachial artery has a name, as does the broad ligament. Continuous tumor growth from one organ into an adjacent named structure would be coded to 600 in the schemas for ill-defined or non-specific sites.

Code	Description	TNM 7 Map	TNM 6 Map	SS77 Map	SS2000 Map
000	In situ, intraepithelial, noninvasive	NA	NA	IS	IS
100	Invasion of submucosa	NA	NA	L	L
300	Localized, NOS	NA	NA	L	L
400	Adjacent connective tissue(s) (See Note 1)	NA	NA	RE	RE
600	Adjacent organ(s)/structure(s) (See Note 2)	NA	NA	RE	RE
700	Regional extension, NOS	NA	NA	RE	RE
800	Further contiguous extension	NA	NA	D	D
950	No evidence of primary tumor	NA	NA	U	U
999	Unknown; extension not stated Primary tumor cannot be assessed Not documented in patient record	NA	NA	U	U

CS Extension