Collaborative Stage Data Set - Revised 05/24/2013 FINAL

Appendix

CS Site-Specific Factor 11
Histopathologic Grading

Note 1: Histologic grading is used to distinguish between IVA and IVB anatomic stage/prognostic groups. It is considered to be of particular importance for mucinous carcinomas (morphology codes 8480, 8481, and 8490).
Note 2: Select the code for the highest grade from the primary tumor tissue as described on the pathology report prior to neoadjuvant treatment.
Note 3: The term "undifferentiated" should not apply to mucinous tumors because a tumor that makes mucin is, by definition, differentiated into mucin-producing tumor cells.

Code	Description
010	For NON-MUCINOUS tumors: Well differentiated Grade 1/4
011	For MUCINOUS tumors: Grade 1/2 Grade 1/3 Grade 1/4 Low grade Well differentiated Stated as Grade 1 with no information on the total number of codes in the grading system
020	For NON-MUCINOUS tumors: Moderately differentiated Grade 2/4
021	For MUCINOUS tumors: Grade 2/2 Grade 2/3 Grade 2/4 Grade 3/3 Grade 3/4 High grade Moderately differentiated Poorly differentiated Stated as Grade 2 or Grade 3 with no information on the total number of codes in the grading system
030	For NON-MUCINOUS tumors: Poorly differentiated Grade 3/4
040	For NON-MUCINOUS tumors: Undifferentiated Grade 4/4
988	Not applicable: Information not collected for this case (If this information is required by your standard setter, use of code 988 may result in an edit error.)
998	No pathologic confirmation of primary site tumor
999	Unknown or no information Not documented in patient record