MerkelCellSkin

Note 1: AJCC defines microscopic lymph node metastases or "micrometastases" as those which are clinically inapparent by palpation and/or imaging but are pathologicaly positive. Micrometastases are diagnosed after sentinel or other node biopsy or elective lymphadnectomy. "Macrometastases" are clinically detectable nodal metastases confirmed by needle biopsy or therapeutic lymphadenectomy.
Note 2: Use code 005 if nodes are described as clinically negative. Use code 010 if nodes are described as clinically negative but are positive on pathologic examination.
Note 3: Use code 020 if nodes are described as clinically positive.
Note 4: Use code 100 to code information about clinically apparent in transit metastasis with or without occult nodal metastasis. Information about clinically inapparent in transit metastasis ("occult" metastasis found only on pathologic examination) is not collected in this site-specific factor.
Note 5: Use code 150 to code information about nodal involvement with in transit satellite metastasis that are both clinically apparent.
Note 6: Codes 020 and 150 are appropriate for cases with neoadjuvant treatment, where nodes are described as clinically positive before treatment but are shown to be either negative or positive on pathologic examination after treatment.
Note 7: Use code 999 if no information is available about the clinical evaluation of lymph nodes or in transit metastasis.

Code	Description
000	OBSOLETE DATA RETAINED V0204 No lymph node metastases In-transit metastases WITHOUT regional lymph node involvement
005	Clinically negative lymph node metastases AND No pathologic examination performed Or unknown if pathologic examination performed or nodes negative on pathologic examination
010	Clinically occult lymph node metastases only (micrometastases) Isolated tumor cells (ITCs) only
020	Clinically apparent lymph node metastases (macrometastases)
100	Clinically apparent in transit metastasis WITH or WITHOUT occult nodal metastasis
150	Clinically apparent in transit metastasis and clinically apparent nodal metastasis
888	OBSOLETE DATA CONVERTED V0200 See code 988 Not applicable for this site
988	Not applicable: Information not collected for this case (May include cases converted from code 888 used in CSv1 for "Not applicable" or when the item was not collected. If this item is required to derive T, N, M, or any stage, use of code 988 may result in an error.)
999	Unknown clinically if regional lymph nodes involved Unknown or no information about clinical nodal involvement Clinical nodal involvement not documented in patient record

CS Site-Specific Factor 3Clinical Status of Lymph Node Mets