Collaborative Stage

Note 1: Code only regional nodes and nodes, NOS, in this field. Distant nodes such as cervical (excluding supraclavicular) or contralateral axillary are coded in the field Mets at DX.
Note 2: If the pathology report indicates that nodes are positive but size of the metastases is not stated, assume the metastases are greater than 0.2 mm and code the lymph nodes as positive in this field. Use code 600 in the absence of other information about regional nodes.
Note 3: In a physical exam if palpable nodes are not described as fixed, assume that nodes are movable.
Note 4: Codes 130-600 are used for positive axillary nodes . Axillary lymph nodes refer to level I and level II ipsilateral axillary lymph nodes and ipsilateral intramammary nodes only. It does not include ipsilateral level III axillary lymph nodes which are also known as infraclavicular or apical nodes and are coded in 750 or higher. Axillary does not include internal mammary or ipsilateral supraclavicular lymph nodes.
Note 5: If no lymph nodes were removed for evaluation (Reg Nodes Eval code 0 or 1) or if it is unknown if lymph nodes were removed (Reg Nodes Eval code 9), or if neoadjuvant therapy was given and clinical lymph node involvement is AS extensive or MORE extensive than pathologic lymph node involvement (Reg Nodes Eval code 5), then use only the following codes for clinical evaluation of regional nodes: 000, 255, 260, 290, 510, 600, 740, 745, 750, 760, 780, 790,800, and 999. Do not use codes 290 and 510 when Reg Nodes Eval 2, 3, 6, or 8.
Note 6: Isolated tumor cells (ITC) are defined as single tumor cells or small clusters not greater than 0.2 mm, usually detected only by immunohistochemical (IHC) or molecular methods but which may be verified on H and E stains. ITCs do not usually show evidence of malignant activity (e.g., proliferation or stromal reaction). Lymph nodes with ITCs only are not considered positive lymph nodes. If the record only states N0(i+), code to 000 and see CS SSF-4.
Note 7: Unless nodes are stated to be fixed or matted, assume that they are moveable.

* For code 000 ONLY, the N category is assigned based on the coding of Site-Specific Factors 4 and 5 using the IHC MOL Table for this site.
^ For code 000 ONLY, the N category is assigned based on the coding of Site-Specific Factors 4 and 5 using the IHC MOL Table for this site.
** For codes 250, 260, 280, 290, 300, 500, 510, 520, 600, and 720 ONLY, the N category is assigned based on the values of Site-Specific Factor 3 (Number of Positive Ipsilateral Axillary Lymph Nodes) and CS Reg Nodes Eval. If the Eval code is 2 (p), 3 (p), 6 (y), or 8 (a), the N category is determined by reference to the Lymph Nodes Pathologic Evaluation Table. If the Eval code is 0 (c), 1(c), 5(c), or 9 (c), the N category is determined by reference to the Lymph Nodes Clinical Evaluation Table. If the Eval field is not coded, the N category is determined by reference to the Lymph Nodes Positive Axillary Node Table.
^^ For codes 250, 260, 280, 290, 300, 500, 510, 520, 600, and 720 ONLY, the N category is assigned based on the values of Site-Specific Factor 3 (Number of Positive Ipsilateral Axillary Lymph Nodes) and CS Reg Nodes Eval. If the Eval code is 2 (p), 3 (p), 6 (y), or 8 (a), the N category is determined by reference to the Lymph Nodes Pathologic Evaluation Table. If the Eval code is 0 (c), 1(c), 5(c), or 9 (c), the N category is determined by reference to the Lymph Nodes Clinical Evaluation Table. If the Eval field is not coded, the N category is determined by reference to the Lymph Nodes Positive Axillary Node Table.

Code	Description	TNM 7 Map	TNM 6 Map	SS77 Map	SS2000 Map
000	None; no regional lymph node involvement, or ITCs detected by immunohistochemistry or molecular methods ONLY. (See Note 6 and Site-specific Factors 4 and 5.)	^	*	NONE	NONE
050	None; no regional lymph node(s) but with (ITCs) detected on routine H and E stains. (See Note 6)	N0(i+)	N0(i+)	NONE	NONE
130	Axillary lymph node(s), ipsilateral, micrometastasis ONLY detected by immunohistochemical (IHC) means ONLY (at least one micrometastasis greater than 0.2 mm or more than 200 cells and all micrometastases less than or equal to 2 mm)	N1mi	N1mi	RN	RN
150	Axillary lymph node(s), ipsilateral, micrometastasis ONLY detected or verified on H&E (at least one micrometastasis greater than 0.2 mm (or more than 200 cells) and all micrometastases less than or equal to 2 mm) Micrometastasis, NOS	N1mi	N1mi	RN	RN
250	Movable axillary lymph node(s), ipsilateral, positive with more than micrometastasis (i.e., at least one metastasis greater than 2 mm) (See Note 7.)	^^	**	RN	RN
255	Clinically movable axillary lymph node(s), ipsilateral, positive (clinical assessment because of neoadjuvant therapy or no pathology)(See Note 7.)	N1	N1	RN	RN
260	Stated as N1, NOS	N1	**	RN	RN
280	OBSOLETE DATA RETAINED V0200- Stated as N2, NOS	ERROR	**	RN	RN
290	Clinically stated only as N2, NOS (clinical assessment because of neoadjuvant therapy or no pathology)	N2NOS	**	RN	RN
300	Pathologically stated only as N2 NOS; no information on which nodes were involved	^^	**	RN	RN
500	OBSOLETE DATA RETAINED V0200- Fixed/matted ipsilateral axillary nodes, positive with more than micrometastasis (i.e., at least one metastasis greater than 2 mm) Fixed/matted ipsilateral axillary nodes, NOS	ERROR	**	RN	RN
510	Fixed/matted ipsilateral axillary nodes clinically (clinical assessment because of neoadjuvant therapy or no pathology) Stated clinically as N2a, NOS (clinical assessment because of neoadjuvant therapy or no pathology)	^^	**	RN	RN
520	Fixed/matted ipsilateral axillary nodes clinically with pathologic involvement of lymph nodes at least one metastasis greater than 2mm	^^	**	RN	RN
600	Axillary/regional lymph node(s), NOS Lymph nodes NOS	^^	**	RN	RN
710	Internal mammary node(s), ipsilateral, positive on sentinel nodes but not clinically apparent (no positive imaging or clinical exam) WITHOUT axillary lymph node(s), ispilateral	N1b	N1b	RN	RN
720	Internal mammary node(s), ipsilateral, positive on sentinel nodes but not clinically apparent (no positive imaging or clinical exam) WITH axillary lymph node(s), ispilateral	^^	**	RN	RN
730	Internal mammary node(s), ipsilateral, positive on sentinel nodes but not clinically apparent (no positive imaging or clinical exam) UNKNOWN if positive axillary lymph node(s), ispilateral	N1b	N1b	RN	RN
740	Internal mammary node(s), ipsilateral, clinically apparent (on imaging or clinical exam) WITHOUT axillary lymph node(s), ispilateral	N2b	N2b	RN	RN
745	Internal mammary node(s), ipsilateral, clinically apparent (on imaging or clinical exam) and UNKNOWN if positive axillary lymph node(s), ispilateral	N2b	N2b	RN	RN
750	Infraclavicular lymph node(s)(subclavicular) (level III axillary nodes) (apical), ispilateral	N3a	N3a	D	RN
760	Internal mammary node(s), ipsilateral, clinically apparent (on imaging or clinical exam) WITH axillary lymph node(s), ipsilateral, codes 150 to 600 WITH or WITHOUT infraclavicular (level III axillary nodes) (apical) lymph nodes	N3b	N3b	RN	RN
770	OBSOLETE DATA RETAINED V0200 Internal mammary node(s), ipsilateral, clinically apparent (on imaging or clinical exam) UNKNOWN if positive axillary lymph node(s), ispilateral	ERROR	N2b	RN	RN
780	OBSOLETE DATA RETAINED V0200 (750) + (770)	ERROR	N3a	D	RN
790	Stated as N3, NOS	N3NOS	N3NOS	RN	RN
800	Supraclavicular node(s), ispilateral	N3c	N3c	D	D
999	Unknown; not stated Regional lymph node(s) cannot be assessed Not documented in patient record	NX	NX	U	U

Breast

CS Lymph Nodes