Collaborative Stage

Note 1: Ki-67 and MIB-1 are labeling indexes used as a complementary method to differentiate better and worse prognostic groups of certain brain tumors. They evaluate the cell kinetics in brain tumors. Code the labeling index fraction percentage using Ki-67 or MIB-1 (monoclonal antibody) when it is available on the final diagnosis of the pathology report of the primary brain tumor.
Note 2: Record the Labeling Index (LI) percentage as documented by the pathologist as an exact number (001-100). For instance, if the LI level is recorded by the pathologist as 15%, assign code 015. If percentage is documented as 13.7% round up to 14% and assign code 014. If percentage is documented as 13.2%,, round down to 13% and assign code 013.

Code	Description
001-100	1-100% (code exact Labeling Index percentage) Examples: 001 = 1% 010 = 10% 014 = 13.7% 055 = 55.2%
200	Labeling Index normal
300	Labeling Index stated as slightly elevated and no percentage provided
400	Labeling Index stated as elevated and no percentage provided
888	OBSOLETE DATA CONVERTED V0200 See code 988. Not applicable for this schema
988	Not applicable: Information not collected for this case (May include cases converted from code 888 used in CSv1 for "Not applicable" or when the item was not collected. If this item is required to derive T, N, M, or any stage, use of code 988 may result in an error.)
997	Test ordered, results not in chart
998	Test not done (test was not ordered and was not performed)
999	Unknown or no information Not documented in patient record

CS Site-Specific Factor 2
Proliferative Fraction- Ki-67/MIB-1