Collaborative Stage

Note 1: There is evidence that human papillomavirus (HPV) plays a role in the pathogenesis of some cancers.
Note 2: Record the results of any HPV testing performed on pathologic specimens from the primary tumor or a metastatic site, including regional nodes. HPV testing may be performed for prognostic purposes; testing may also be performed on metastatic sites to aid in determination of the primary site.
Note 3: The highest risk HPV types are types 16 and 18. Other high risk types are 31, 33, 35, 36, 45, 51, 52, 56, 58, 59, 68, 26, 53, 66, 67, 69, 70, 73, 82, 85. Low risk types are 6, 11, 32, 34, 40, 42, 44, 54, 61, 62, 64, 71, 72, 74, 81, 83, 84, 87, 89. The HPV vaccine is designed to protect against types 16 and 18 (associated with cervical cancer) and types 6 and 11 (associated with genital warts).
Note 4: High risk may be abbreviated "hrHPV" or "HR-HPV".
Note 5: Some tests for HPV, such as a hybrid capture test, may only report negative or positive for high risk HPV without identifying types. Use codes 000 or 060, respectively, to report those test results.

Code	Description
000	HPV test negative; not positive for any HPV types Negative, NOS
010	LOW RISK positive (all positive type(s) are low risk)
020	HIGH RISK positive, specified type(s) other than types 16 or 18, WITH or WITHOUT positive results for low risk type(s)
030	HIGH RISK positive for HPV 16 WITHOUT positive results for HPV 18 or positivity of HPV 18 unknown, WITH or WITHOUT positive results for other high-risk types, WITH or WITHOUT positive results for low risk type(s)
040	HIGH RISK positive for HPV 18 WITHOUT positive results for HPV 16 or positivity of HPV 16 unknown, WITH or WITHOUT positive results for other high-risk types, WITH or WITHOUT positive results for low risk type(s)
050	HIGH RISK positive for HPV 16 AND HPV 18, WITH or WITHOUT positive results for other high-risk types, WITH or WITHOUT positive results for low risk type(s)
060	HIGH RISK positive, NOS, type(s) not specified
070	Positive, NOS, risk and type(s) not stated
988	Not applicable: Information not collected for this case
997	Test ordered, results not in chart
998	Test not done (test was not ordered and was not performed), including no pathologic specimen available for HPV testing
999	Unknown or no information Not documented in patient record

CS Site-Specific Factor 12
HPV (Human Papilloma Virus) Status